Scientific Staff

Dr. Anvita KaleAssistant Professor

Bharati Vidyapeeth, Pune

Date of Birth :31/08/1972

Department : Mother and child Health

Phone : 020-24366920 (ext.311)

Educational Qualification : M.Sc. PhD Biochemistry

Research experience : 25 year

Research Projects Ongoing as Co-Investigator:

Centre for Advanced Research in “Mechanisms leading to Preeclampsia” funded by Indian Council for Medical Research (ICMR), India.(March 2017-March 2022).
Disturbed Maternal 1-Carbon Cycle in Preeclampsia Increases Risk for Cardiometabolic Variables in Children.

Research Projects Completed as Co-Investigator:

Maternal micronutrient status, inflammatory markers and Risk for non-communicable diseases in the offspring in a preeclamptic rat model funded by department of biotechnology (DBT), India. (March 2013-April 2016).
Multigenerational effects of vitamin B12 deficiency/supplementation on brain development and metabolic syndrome variables in a rat model funded by department of science and technology (DST), India. (Aug 2011-Nov 2014).
Regulation of Fatty acid desaturases and transport proteins by maternal micronutrients in human placenta funded by Indian Council for Medical Research (ICMR), India (Aug 2012- June 2013)
Role of maternal micronutrients on brain neurotrophic factors and cognitive development in Wistar rat offspring, funded by department of biotechnology (DBT), India. (March 2010-Feb 2013).

Awards

Recipient of the best poster award (for experimental nutrition) for the paper titled “Short and long term effects of maternal butter consumption on adult wistar rat offspring cardiometabolic and neurodevelopmental health” and authors Shruti Jawale, Sadhana Joshi, Anvita Kale *at the 50th National Conference by the Nutrition Society of India is being organized at Hyderabad from the 15th to 17th of November 2018.
Recipient of the Seva Gaurav Puraskar ”Best Researcher Award”, Bharati Vidyapeeth (Deemed to be University), 26th April 2016.
Recipient of the best poster award (for experimental nutrition) for the paper titled “Association Of One-Carbon Metabolism (Reduced Folic Acid, Vitamin B12), Docosahexaenoic Acid And Homocysteine Concentrations In Patients With Schizophrenia” at the 41st Annual meet of the Nutrition Society of India. 20th and 21st Nov 2009 at Hyderabad.
Recipient of RAMANATHAN AWARD for the best oral presentation for the paper titled “Essential Polyunsaturated Fatty Acids and Nerve Growth Factor Levels In First Episode Schizophrenia” in the Free Communication Session of the 39th National Conference of the Nutrition Society of India held at National Institute of Nutrition, Nov 15th-16th 2007 at Hyderabad.
The best poster award (for experimental nutrition) was awarded to the paper titled “Sensitivity Of Fetus To Of Alpha Linolenic Acid – An Essential Omega Three Fatty Acid” at the XXXVI Annual meet of the Nutrition Society of India This award was instituted by the organizers CFTRI, DFRL and University of Mysore., 5th - 6th Nov 2004 at Mysore.

Memberships

Life member of Nutrition Society of India, India
Life member of Society for the natal effects on health in adults (SNEHA), India

NAAC, NIRF, UGC Coordinator for the institute for the year 2015-16.

Fellowships

Recipient of CSIR (Council for Industrial and Scientific Research fellowship) 1994 December.
This is a national fellowship awarded for training in methods of research under the expert guidance of faculty members /scientists working in University Departments/ National Laboratories and Institutes in various fields of Science & Technology and Medical Sciences in India.
Recipient of NCL fellowship for the period of 1993-1995 for Masters in Biochemistry from Pune University.
This is a national merit fellowship is awarded to 10 candidates annually based on a national examination conducted for over 5000 students.

Publications

Total: 37
Book Chapter:1

Papers Presented In International Conferences: 25

Papers Presented In National Conferences: 22

Resource Person for the CME on Basic Techniques in Research Methodology for Ayurveda “Analysis of biological fluids” held from 27th Feb to 4th March 2017 at the Interactive Research School for Health Affairs, Bharati Vidyapeeth (Deemed to be University), Pune

Research Programmes

Neurodevelopmental disorders impair growth and development of the brain in the womb (Reynolds et al., 1999). These disorders affect approximately 12% of the global burden of disease (Reddy et al., 2013) and associated with cognitive impairment (Anjos et al., 2013). The neurodevelopmental disorders include attention deficit hyperactivity disorder (ADHD), autism (ASD), schizophrenia and dyslexia. Nutrition is one of the factors influencing the neurodevelopmental outcome. Our group will focus on the role of omega-3 fatty acids and explore the possible mechanisms through which omega 3 fatty acids may influence brain growth and development in these neurodevelopmental disorders.

The emerging role of gestational factors especially micronutrients like folic acid, vitamin B12 and omega-3 fatty acids in shaping the brain and on the influence of these intrauterine experiences on later development of neurodevelopmental disorders is my focus area of research. The nine months of intrauterine development and the first three years of postnatal life are critical for periods of development. Further, the importance of these nutrients arises from the fact that an Indian population has a low consumption of omega-3 fatty acids and is known to be deficient in Vitamin B12. Currently due to Westernisation there is also an increased consumption of a high fat diet. Further, there is a rise in burden of mental disorders in developing coutries and a need to explore the underlying mechanisms.

Publication

Kasture V, Dalvi S, Swamy M, Kale A, Joshi S. Omega-3 fatty acids differentially influences embryotoxicity in subtypes of preeclampsia.Clin Exp Hypertens. 2019 Apr 9:1-8. doi:10.1080/10641963.2019.1601208. [Epub ahead of print]
Shruti Jawale, Sadhana Joshi, Anvita Kale* . Maternal Dairy Fat Diet does not Influence Neurotrophin Levels and Cognitive Performance in the Rat Offspring at Adult Age. International Journal of Developmental Neuroscience. 2018 71:18-29 (IF:2.495).
Kemse N, Kale A, Chavan-Gautam P, Joshi S. Increased intake of vitamin B12, folate, and omega-3 fatty acids to improve cognitive performance in offspring born to rats with induced hypertension during pregnancy.Food Funct. 2018 Jul 17;9(7):3872-3883. doi: 10.1039/c8fo00467f. (IF:3.247)
Kemse N, Sundrani D, Kale A, Joshi S. Maternal Micronutrients, Omega-3 Fatty Acids and Gene Expression of Angiogenic and Inflammatory Markers in Pregnancy Induced Hypertension Rats. Arch Med Res. 2017 Jul;48(5):414-422. doi:10.1016/j.arcmed.2017.10.006. Epub 2017 Nov 10. (IF:2.718).
Rathod R, Khaire A, Kale A, Joshi S. A combined supplementation of vitamin B12 and n-3 polyunsaturated fatty acids across two generations improves nerve growth factor and vascular endothelial growth factor levels in the rat hippocampus.Neuroscience. 2016 Dec 17;339:376-384. doi: 10.1016/j.neuroscience.2016.10.018. (IF: 3.231).
Khaire A, Rathod R, Kale A, Joshi S (2016). Vitamin B12 Deficiency across Three Generations Adversely Influences Long Chain Polyunsaturated Fatty Acid Status and Cardiometabolic Markers in Rats. Archives of Medical Research. 2016 Aug;47(6):427-435.(IF:2.219)
Jawale S, Pulwale A, Joshi S, Kale A. Maternal high fat diet deficient in vitamin B12 influences long chain polyunsaturated fatty acid composition in rats. J Matern Fetal Neonatal Med. 2016 Nov 21:1-9. [Epub ahead of print] (IF:1.089)
RS, Khaire AA, Kale AA, Joshi SR. Effect of vitamin B12 and omega-3 fatty acid supplementation on brain neurotrophins and cognition in rats: A multigeneration study.Biochimie. 2016 Sep-Oct;128-129:201-8. doi: 10.1016/j.biochi.2016.08.009. (IF:3.017)
Khaire A, Rathod R, Randhir K, Kale A, Joshi S. A combined supplementation of vitamin B12 and omega-3 fatty acids across two generations improves cardiometabolic variables in rats.Food Funct. 2016 Sep 14;7(9):3910-9. doi: 10.1039/c6fo00148c. (IF: 2.686).
Kemse NG, Kale AA, Joshi SR (2016). Maternal supplementation of omega-3 fatty acids and micronutrients reduces cardiometabolic variables in pregnancy induced hypertension rats.Life Sciences. Jun 15;155:85-93. (IF: 2.685).
Kemse NG, Kale AA, Joshi SR. Supplementation of maternal omega-3 fatty acids to pregnancy induced hypertension Wistar rats improves IL10 and VEGF levels. Prostaglandins Leukot Essent Fatty Acids. 2016 Jan;104:25-32. doi: 10.1016/j.plefa.2015.11.003. (IF:3.155).
Rathod R, Kale A, Joshi S. Novel insights into the effect of vitamin B12 and omega-3 fatty acids on brain function. J Biomed Sci. 2016 Jan 25;23:17. doi: 10.1186/s12929-016-0241-8. Review. (IF: 2.736).
Rathod RS, Khaire AA, Kale AA, Joshi SR. Beneficial effects of omega-3 fatty acids and vitamin B12 supplementation on brain docosahexaenoic acid, brain derived neurotrophic factor, and cognitive performance in the second-generation Wistar rats. Biofactors. 2015 JulAug;41(4):261-72. doi: 10.1002/biof.1222. (IF: 4.504).
Khaire AA, Kale AA, Joshi SR. Maternal omega-3 fatty acids and micronutrients modulate fetal lipid metabolism: A review. Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:49- 55. doi: 10.1016/j.plefa.2015.04.007. Review. (IF: 3.155).
Rathod RS, Khaire AA, Kale AA, Joshi SR. Maternal omega-3 fatty acid supplementation to a vitamin B12 deficient diet normalizes angiogenic markers in the pup brain at birth. Int J Dev Neurosci. 2015 Jun;43:43-9. doi: 10.1016/j.ijdevneu.2015.04.006. (IF: 2.380)
Khaire A, Rathod R, Kale A, Joshi S. Vitamin B12 and omega-3 fatty acids together regulate lipid metabolism in Wistar rats. Prostaglandins Leukot Essent Fatty Acids. 2015 Aug;99:7-17. doi: 10.1016/j.plefa.2015.04.006. (IF: 3.155).
Khaire A, Rathod R, Kemse N, Kale A, Joshi S. Supplementation with omega-3 fatty acids during gestation and lactation to a vitamin B12-deficient or -supplemented diet improves pregnancy outcome and metabolic variables in Wistar rats. Reprod Fertil Dev. 2015 Jan;27(2):341-50. doi: 10.1071/RD13306. (IF: 2.400).
Sable P, Randhir K, Kale A, Chavan-Gautam P, Joshi S. Maternal micronutrients and brain global methylation patterns in the offspring. Nutr Neurosci. 2015 Jan;18(1):30-6. doi:10.1179/1476830513Y.0000000097. (IF: 2.616)
Kemse NG, Kale AA, Joshi SR. A combined supplementation of omega-3 fatty acids and micronutrients (folic acid, vitamin B12) reduces oxidative stress markers in a rat model of pregnancy induced hypertension. PLoS One. 2014 Nov 18;9(11):e111902. doi:10.1371/journal.pone.0111902. (IF: 3.057).
Rathod R, Khaire A, Kemse N, Kale A, Joshi S. Maternal omega-3 fatty acid supplementation on vitamin B12 rich diet improves brain omega-3 fatty acids, neurotrophins and cognition in the Wistar rat offspring. Brain Dev. 2014 Nov;36(10):853-63. doi:10.1016/j.braindev.2013.12.007. (IF: 1.785).
Khot V, Kale A, Joshi A, Chavan-Gautam P, Joshi S. Expression of genes encoding enzymes involved in the one carbon cycle in rat placenta is determined by maternal micronutrients (folic acid, vitamin B12) and omega-3 fatty acids. Biomed Res Int. 2014;2014:613078. doi:0.1155/2014/613078. (IF: 1.579)
Sable P, Kale A, Joshi A, Joshi S. Maternal micronutrient imbalance alters gene expression of BDNF, NGF, TrkB and CREB in the offspring brain at an adult age. Int J Dev Neurosci.2014 May;34:24-32. doi: 10.1016/j.ijdevneu.2014.01.003. (IF: 2.380)
Roy S, Sable P, Khaire A, Randhir K, Kale A, Joshi S. Effect of maternal micronutrients (folic acid and vitamin B12) and omega 3 fatty acids on indices of brain oxidative stress in the offspring. Brain Dev. 2014 Mar;36(3):219-27. doi: 10.1016/j.braindev.2013.03.004. (IF: 1.785)
Sable PS, Kale AA, Joshi SR. Prenatal omega-3 fatty acid supplementation to a micronutrient imbalanced diet protects brain neurotrophins in both the cortex and hippocampus in the adult rat offspring. Metabolism. 2013 Nov;62(11):1607-22. doi: 10.1016/j.metabol.2013.06.002.(IF: 4.375)
Roy S, Kale A, Dangat K, Sable P, Kulkarni A, Joshi S. Maternal micronutrients (folic acid and vitamin B(12)) and omega 3 fatty acids: implications for neurodevelopmental risk in the rat offspring. Brain Dev. 2012 Jan;34(1):64-71. doi: 10.1016/j.braindev.2011.01.002. (IF:1.785)
Sable P, Dangat K, Kale A, Joshi S (2011). Altered brain neurotrophins at birth: consequence of Imbalance in maternal folic acid and vitamin B12 metabolism. Neuroscience Sept: 190:127-34 (IF: 3.327)
Dangat KD, Kale AA, Joshi SR. Maternal supplementation of omega 3 fatty acids to micronutrient-imbalanced diet improves lactation in rat. Metabolism. 2011 Sep;60(9):1318-24. doi: 10.1016/j.metabol.2011.02.001. (IF: 4.375)
Kulkarni A, Dangat K, Kale A, Sable P, Chavan-Gautam P, Joshi S. Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats. PLoS One. 2011 Mar 10;6(3):e17706. doi: 10.1371/journal.pone.0017706. (IF: 3.057)
Kilari A, Mehendale S, Pisal H, Panchanadikar T, Kale A, Joshi S. Nerve growth factor, birth outcome and pre-eclampsia. Int J Dev Neurosci. 2011 Feb;29(1):71-5. doi:10.1016/j.ijdevneu.2010.09.001. (IF: 2.380).
Kale A, Naphade N, Sapkale S, Kamaraju M, Pillai A, Joshi S, Mahadik S. Reduced folic acid, vitamin B12 and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: implications for altered one-carbon metabolism. Psychiatry Res. 2010 Jan 30;175(1-2):47-53. doi: 10.1016/j.psychres.2009.01.013. (IF:2.682).
Pillai A, Kale A, Joshi S, Naphade N, Raju MS, Nasrallah H, Mahadik SP. Decreased BDNF levels in CSF of drug-naive first-episode psychotic subjects: correlation with plasma BDNF and psychopathology. Int J Neuropsychopharmacol. 2010 May;13(4):535-9. doi:10.1017/S1461145709991015. (IF: 4.009).
Kale A, Joshi S, Pillai A, Naphade N, Raju M, Nasrallah H, Mahadik SP. Reduced cerebrospinal fluid and plasma nerve growth factor in drug-naïve psychotic patients. Schizophr Res. 2009 Dec;115(2-3):209-14. doi: 10.1016/j.schres.2009.07.022. (IF: 4.748).
Kale A, Joshi S, Naphade N, Sapkale S, Raju MS, Pillai A, Nasrallah H, Mahadik SP.Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients. Schizophr Res. 2008 Jan;98(1-3):295-301. (IF: 4.748).
Rao SS, Kale AA, Joshi SR, Mahadik SP. Sensitivity of fetus and pups to excess levels of maternal intakes of alpha linolenic acid at marginal protein levels in Wistar rats. Reprod Toxicol. 2007 Nov-Dec;24(3-4):333-42. (IF: 2.771).
Rao S, Joshi S, Kale A, Hegde M, Mahadik S. Maternal folic acid supplementation to dams on marginal protein level alters brain fatty acid levels of their adult offspring. Metabolism. 2006 May;55(5):628-34. (IF: 4.375)
Joshi S, Rao S, Girigosavi S, Daware M, Kale A, Hegde M. Differential effects of fish oil and folic acid supplementation during pregnancy in rats on cognitive performance and serum glucose in their offspring. Nutrition. 2004 May;20(5):465-72. (IF: 3.046).
Ranjekar PK, Hinge A, Hegde MV, Ghate M, Kale A, Sitasawad S, Wagh UV, Debsikdar VB, Mahadik SP. Decreased antioxidant enzymes and membrane essential polyunsaturated fatty acids in schizophrenic and bipolar mood disorder patients. Psychiatry Res. 2003 Dec 1;121(2):109-22. (IF: 2.682).