Dr. Deepali SundraniAssistant Professor
Bharati Vidyapeeth, Pune
Date of Birth: 07/11/1985
Qualification: M.Sc. Ph.D (Biotechnology)
Designation: Assistant Professor
Contacts
e-mail: deepali.sundrani@bharatividyapeeth.edu/dips.sundrani@gmail.com
Phone: 020-24366920 (ext.312)
Research experience: 10 years
Area of interest: Mother and Child Health, Epigenetics, Placental Nutrient Transport
Honors/Awards
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DBT Biotechnology Career Advancement and Re- orientation Programme (BioCARe): A Mission Programme of the Department for empowering Women Scientists of India 2019 Award
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Best Poster Presentation at the 19th Annual SNEHA-MRC International workshop on Developmental Origins of Health and Diseases (DOHaD), Hyderabad, 26th – 28th February, 2016.
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Prof. N. R. Moudgal Young Scientist Award-2016 at the 26th Annual Meeting of the Indian Society for the Study of Reproduction and Fertility (ISSRF) along with International Conference on Reproductive Health with Emphasis on Occupational, Environmental & Lifestyle Factors (ISSRF-2016), 18th – 20th February, 2016, at NIOH, Ahmedabad for outstanding contributions in the field of Reproductive Health.
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The “Ramanathan Prize” for the best oral presentation in the Free Communication session at the 45th National Conference of the Nutrition Society of India, Hyderabad 21st – 22nd November 2013.
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The “Young Scientist Award” at the 44th National Conference of the Nutrition Society of India, Tirupati 16th – 17th November, 2012.
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2013-2014: Senior Research Fellowship from Indian Council of Medical Research, Govt. of India
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2014-2016: Research Associateship from Indian Council of Medical Research, Govt. of India
International Training (USA)
Worked as Short-Term Research Scholar in the Knight Cardiovascular Institute Center for Developmental Health at Oregon Health & Science University (OHSU), Portland, Oregon, USA and Department of Pediatrics, University of Colorado Anschutz Medical Campus Aurora, Colorado, USA (September 2016 – November 2016) – Isolation of human placenta plasma membranes (membrane vesicles), Plasma membrane enrichment assays, Isolation of cytotrophoblast cells from term human placenta, Western Blotting, Immunohistochemistry.
National Training
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Worked at CSIR institute, Centre for Cellular and Molecular Biology (CCMB), Hyderabad under the guidance of Dr. Giriraj Chandak to perform gene specific methylation analysis of angiogenic factors using the Sequenom MassARRAY Epityper.
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International Course in Nutrition Research Methods in Nutrition (Bangalore Boston Nutrition Collaborative), St. John’s Institute, Bangalore, 9th – 20th Jan, 2012.
Invited Talks
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Delivered a talk on "Understanding Placental Biology in Pregnancy Complications" in the Young Minds Speak session at the "Provocative Ideas on Human Placental Research" meeting scheduled on December 1st – 2nd, 2015 at Translational Health Science and Technology Institute (THSTI), NCR Biotech Science Cluster, Faridabad, India.
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Delivered a lecture on "Nutrigenomics for a Healthy Future: Recent Developments" at the "International Conference on “Enhancing Health, Wellbeing and Sustainablity-Opportunities, Challenges and Future Directions" on 11th January 2013 held at College of Home Science, Nirmala Niketan, Mumbai.
Professional memberships
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Life membership of Nutrition Society of India
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Life membership of Indian Society for the Study of Reproduction & Fertility
Research Programme
Maternal nutrition plays a critical role in fetal development and determines the health of the offspring in early and later life. Human epidemiological studies have shown that alterations in key developmental processes in utero can predispose the offspring to many late-onset diseases. The placenta responds to perturbations in the maternal compartment, such as altered nutrition and reduced utero-placental blood flow thereby, playing a key role in programming the fetus to diseases. These programmed changes are likely to be a result of stable changes in the gene expression patterns which are influenced by epigenetic modifications. Epigenetics is the study of changes in gene expression without any alterations in the underlying nucleotide sequence. Understanding the influence of epigenetic mechanisms in adverse pregnancy outcomes like preterm birth, preeclampsia and low birth weight is my focus area of research. Further my research also focuses on studying the role of maternal nutrients particularly folate, vitamin B12 and polyunsaturated fatty acids in influencing the placental epigenetic patterns during pregnancy.
Projects as Principal Investigator
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1. Project Title: Epigenetic regulation of placental peroxisome proliferator activated receptor (PPAR) in women delivering low birth weight babies
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Funding Agency: Department of Biotechnology (DBT) (BioCARe 2018 Programme for Women Scientists)
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Amount Sanctioned: 35.51 Lakhs (Rs. 3550683/-)
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Duration: 26th April 2019 to 25th April 2022
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2. Project Title: Epigenetic regulation of angiogenic factors in assisted reproductive technology (ART) and non-ART derived placentae
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Funding Agency: Department of Biotechnology (DBT) (Reproductive Biology Call under Medical Biotechnology - Human Developmental & Disease Biology (HDDB)
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Amount Sanctioned: 59.91 Lakhs (Rs. 5991300/-)
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Duration: 18th July 2019 to 17th July 2022
Project as Co-Investigator
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1. Project Title: Exploring the role of maternal fatty acids, placental fatty acid metabolism, and inflammation in determining infant health in gestational diabetes mellitus
Funding Agency: Department of Biotechnology (DBT)
Amount Sanctioned: 95.51 Lakhs (Rs. 9551840/-)
Duration: 1st Feb 2022 to 31st Jan 2025
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2. Project Title: Understanding the association and underlying molecular mechanisms of early life ‘Double-burden’ of malnutrition and non-communicable disease risk in adolescence
Funding Agency: Department of Biotechnology (DBT)
Amount Sanctioned: 158.9563 Lakhs (Rs. 15895630/-)
Duration: 10th October 2023 to 9th October 2026
Publications:
Total: 43 (40 Papers and 3 Book Chapters)
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1. Joshi N, Jadhav A, Godhamgaonkar A, Sundrani D, Randhir K, Pisal H, Wagh G, Krishnaveni G, Gupte S, Joshi S. Fatty acids and their metabolites (resolvins) are altered in women with gestational diabetes mellitus (GDM). Food Funct. 2024 Mar 18;15(6):3023-3035.
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2. Joshi N, Sahay A, Mane A, Sundrani D, Randhir K, Wagh G, Thornburg K, Powell T, Yajnik C, Joshi S. Altered expression of nutrient transporters in syncytiotrophoblast membranes in preeclampsia placentae. Placenta. 2023 Aug;139:181-189.
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3. Sundrani D, Karkhanis A, Randhir K, Panchanadikar T, Joshi S. MicroRNAs targeting peroxisome proliferator-activated receptor (PPAR) gene are differentially expressed in low birth weight placentae. Placenta. 2023 Jun 8;139:51-60.
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4. Joshi NP, Madiwale SD, Sundrani DP, Joshi SR. Fatty acids, inflammation and angiogenesis in women with gestational diabetes mellitus. Biochimie. 2023 Apr 12;212:31-40.
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5. Kaur L, Sundrani D, Dave K, Randhir K, Mehendale S, Bayyana S, Kalyanaraman K, Chandak GR, Joshi S. Hypoxia Inducible Factors (HIF1α and HIF3α) are differentially methylated in preeclampsia placentae and are associated with birth outcomes. Mol Cell Biochem. 2023 Jan 28.
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6. Joshi NP, Mane AR, Sahay AS, Sundrani DP, Joshi SR, Yajnik CS. Role of Placental Glucose Transporters in Determining Fetal Growth. Reprod Sci. 2022 Oct;29(10):2744-2759.
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7. Dave K, Kaur L, Sundrani D, Sharma P, Bayyana S, Mehendale S, Randhir K, Chandak GR, Joshi S. Association of placental fatty acid desaturase 2 (FADS2) methylation with maternal fatty acid levels in women with preeclampsia. Prostaglandins Leukot Essent Fatty Acids. 2022 Jul 6;184:102472.
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8. Nema J, Joshi N, Sundrani D, Joshi S. Influence of maternal one carbon metabolites on placental programming and long term health. Placenta. 2022 Jul;125:20-28.
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9. Nema J, Randhir K, Wadhwani N, Sundrani D, Joshi S. Maternal vitamin D deficiency reduces docosahexaenoic acid, placental growth factor and peroxisome proliferator activated receptor gamma levels in the pup brain in a rat model of preeclampsia. Prostaglandins Leukot Essent Fatty Acids. 2021 Dec;175:102364.
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10. Kasture V, Sundrani D, Randhir K, Wagh G, Joshi S. Placental apoptotic markers are associated with placental morphometry. Placenta. 2021 Nov;115:1-11.
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11. Sundrani DP, Joshi SR. Assisted reproductive technology (ART) and epigenetic modifications in the placenta. Hum Fertil (Camb). 2021 Oct 27:1-13.
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12. Deshpande JS, Sundrani DP, Sahay AS, Gupte SA, Joshi SR. Unravelling the potential of angiogenic factors for the early prediction of preeclampsia. Hypertens Res. 2021 Jul;44(7):756-769.
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13. Sundrani DP, Karkhanis AR, Joshi SR. Peroxisome Proliferator-Activated Receptors (PPAR), fatty acids and microRNAs: Implications in women delivering low birth weight babies. Syst Biol Reprod Med. 2021 Feb;67(1):24-41.
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14. Dave K, Kaur L, Randhir KN, Mehendale SS, Sundrani DP, Chandak GR, Joshi SR. Placental growth factor and Fms related tyrosine kinase-1 are hypomethylated in preeclampsia placentae. Epigenomics. 2021 Feb;13(4):257-269.
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15. Godhamgaonkar AA, Sundrani DP, Joshi SR. Role of maternal nutrition and oxidative stress in placental telomere attrition in women with preeclampsia. Hypertens Pregnancy. 2021 Feb;40(1):63-74.
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16. Nema J , Sundrani D , Joshi S. Prenatal vitamin D supplementation reduces blood pressure and improves placental angiogenesis in an animal model of preeclampsia. Food Funct. 2020 Dec 1;11(12):10413-10422.
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17. Sahay AS, Jadhav AT, Sundrani DP, Wagh GN, Joshi SR. Differential Expression of Nerve Growth Factor (NGF) and Brain Derived Neurotrophic Factor (BDNF) in Different Regions of Normal and Preeclampsia Placentae. Clin Exp Hypertens. 2020 May 18;42(4):360-364.
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18. Kasture V, Kale A, Randhir K, Sundrani D, Joshi S. Effect of maternal omega-3 fatty acids and vitamin E supplementation on placental apoptotic markers in rat model of early and late onset preeclampsia. Life Sci. 2019 Dec 15;239:117038.
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19. Kasture V, Sundrani D, Dalvi S, Swamy M, Kale A, Joshi S. Maternal omega-3 fatty acids and vitamin E improve placental angiogenesis in late-onset but not early-onset preeclampsia. Mol Cell Biochem. 2019 Nov;461(1-2):159-170.
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20. Nema J, Sundrani D, Joshi S. Role of vitamin D in influencing angiogenesis in preeclampsia. Hypertens Pregnancy. 2019 Nov;38(4):201-207.
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21. Wadhwani NS, Sundrani DP, Wagh GN, Mehendale SS, Tipnis MM, Joshi PC, Kinare AS, Lalwani SK, Mani NS, Chandhiok N, Chandak GR, Gupte SA, Fall CHD, Joshi SR. The REVAMP study: research exploring various aspects and mechanisms in preeclampsia: study protocol. BMC Pregnancy Childbirth. 2019 Aug 23;19(1):308.
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22. Kasture V, Sundrani D, Joshi S. Maternal one carbon metabolism through increased oxidative stress and disturbed angiogenesis can disturb placental angiogenesis in preeclampsia. Life Sci. 2018;206:61-69.
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23. Sahay A, Jadhav A, Sundrani D, Wagh G, Mehendale A, Joshi S. Matrix metalloproteinases-2 (MMP-2) and matrix metalloproteinases-9 (MMP-9) are differentially expressed in different regions of normal and preeclampsia placentae. J Cell Biochem. 2018;119(8):6657-6664.
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24. Sundrani D, Narang A, Mehendale S, Joshi S, Chavan-Gautam P. Investigating the expression of MMPs and TIMPs in preterm placenta and role of CpG methylation in regulating MMP-9 expression. IUBMB Life. 2017 Dec;69(12):985-993.
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25. Kemse N, Sundrani D, Kale A, Joshi S. Maternal micronutrients, omega-3 fatty acids and gene expression of angiogenic and inflammatory markers in pregnancy induced hypertension rats. Arch Med Res. 2017;48(5):414-422.
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26. Sahay A, Jadhav A, Sundrani D, Wagh G, Mehendale S, Chavan-Gautam P, Joshi S. VEGF and VEGFR1 levels in different regions of the normal and preeclampsia placentae. Mol Cell Biochem. 2018 Jan;438(1-2):141-152.
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27. Khot V, Yadav D, Shrestha S, Kaur L, Sundrani D, Chavan-Gautam P, Mehendale S, Chandak G, Joshi S. Hypermethylated CpG sites in the MTR Gene Promoter in Preterm Placenta. Epigenomics. 2017 Jul;9(7):985-996.
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28. Sundrani D, Roy S, Jadhav A, Joshi S. Sex-Specific Differences and Developmental Programming for Diseases in Later Life. Reprod Fertil Dev. 2017 Oct;29(11):2085-2099.
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29. Sahay A, Sundrani D, Joshi S. Regional changes of placental vascularization in preeclampsia: A review. IUBMB Life 2015; 67:619-25.
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30. Sahay A, Sundrani D, Wagh G, Mehendale S, Joshi S. Neurotrophin levels in different regions of the placenta and their association with birth outcome and blood pressure. Placenta 2015; 36:938-43.
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31. Meher A, Sundrani D, Joshi S. Maternal nutrition influences angiogenesis in the placenta through peroxisome proliferator activated receptors: A novel hypothesis. Mol Reprod Dev 2015; 82:726-34.
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32. Sahay A, Sundrani D, Wagh G, Mehendale S, Joshi S. Regional differences in the placental levels of oxidative stress markers in pre-eclampsia. Int J Gynaecol Obstet 2015; 129:213-8.
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33. Sundrani D, Reddy U, Chavan-Gautam P, Mehendale S, Chandak G, Joshi S. Altered methylation and expression patterns of genes regulating placental angiogenesis in preterm pregnancy. Reprod Sci 2014; 21:1508-17.
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34. Sahay A, Patil V, Sundrani D, Joshi A, Wagh G, Gupte S, Joshi S. A longitudinal study of circulating angiogenic, anti-angiogenic factors and AT1-AA levels in preeclampsia. Hypertens Res 2014; 37:753-8.
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35. Sundrani D, Reddy U, Joshi A, Mehendale S, Chavan-Gautam P, Hardikar A, Chandak G, Joshi S. Differential placental methylation and expression of VEGF, FLT-1 and KDR genes in human term and preterm preclampsia. Clin Epigenetics 2013; 5:6.
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36. Sundrani D, Chavan Gautam P, Pisal H, Mehendale S, Joshi S. Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites.. Reproduction 2013; 145:401-10.
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37. Sundrani D, Khot V, Pisal H, Mehendale S, Wagh G, Joshi A, Joshi S. Gestation dependant changes in angiogenic factors and their associations with fetal growth measures in normotensive pregnancy. PLoS One 2013; 8:e54153.
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38. Sundrani D, Chavan Gautam P, Pisal H, Mehendale S, Joshi S. Matrix metalloproteinase-1 and -9 in human placenta during spontaneous vaginal delivery and caesarean sectioning in preterm pregnancy. PLoS One 2012; 7:e29855.
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39. Sundrani D, Chavan Gautam P, Mehendale S, Joshi S. Altered metabolism of maternal micronutrients and omega 3 fatty acids epigenetically regulate matrix metalloproteinases in preterm pregnancy: A novel hypothesis. Med Hypotheses 2011; 77:878-83.
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40. Sundrani D, Chavan-Gautam P, Pisal H, Nimbargi V, Mehendale S, Joshi S. Gestation-dependent changes in human placental global DNA methylation levels. Mol Reprod Dev 2011; 78:150.
Book Chapters
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1. Dave K, Sundrani D, Joshi S (2021). Influence of nutrition on reproductive health through epigenetic mechanisms. Epigenetics and Reproductive Health. (Published by Elsevier)
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2. Sahay A, Sundrani D, Joshi S (2016). Neurotrophins: Role in placental growth and development. Neurotrophins. Edited by Dr. Gerald Litwack. (Published by Elsevier).
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3. Sundrani D, Khot V, Joshi S (2015). DNA methylation for prediction of adverse pregnancy outcome. Chapter 18. Section 3, Epigenetic Biomarkers and Clinical Applications. Volume, Epigenetic Biomarkers and Diagnostics. Series, Translational Epigenetics. Edited by Dr. Jose Luis Garcia-Gimenez. Pg no 351376. (Published by Elsevier)