0 Bharati Vidyapeeth
icon
icon
Back to University

41

Dr. M. V. Hegde Scientific Advisor

Bharati Vidyapeeth, Pune

Date of Birth : 26-04-1939

Department : Innovation Nutrition, IRSHA, BV (DU)

Phone : +91-20-24366920 (Ext. 500)/+91-9922070170

Educational Qualification : B.Sc.(Hons),M.Sc.,PhD

Designations :

  • Scientific Advisor, Interactive Research School for Health Affairs (IRSHA)
  • Director, Centre for innovation in Nutrition Health and Disease, IRSHA,
  • Coordinator, ICAR, Linseed Value Addition Centre
  • Director, Real World Nutrition Laboratory Foundation, Pune

Profile :

It is with extensive post graduate biochemistry teaching experience of over 33 years at Pune University, (now named as Savitribai Phule University) and three years of experience of management of projects on role of omega-3 fatty acids in psychiatric diseases at National Chemical Laboratory, I joined newly formed Interactive Research School for Health Affairs (IRSHA) in the year 2000. Having worked as visiting scientist at Sloan Kettering Cancer Centre, New York, and with Molecular Biology training under Professor Julius Marmur at Albert Einstein College of Medicine New York, I had imbibed the basic UpToDate knowledge of Molecular Biochemistry, ready to take up bigger challenge of focused research and development activities at Bharati Vidyapeeth Deemed to be University as Scientific Advisor, under the leadership of then Director, Dr. Ulhas Wagh, right from inception of IRSHA. We had by then recognised that our modern diet is painfully deficient in omega-3 fatty-acid and very excessive in omega-6 fatty acid, and is one of the major root causes of rising non communicable diseases, such as cardiovascular diseases. diabetes, respiratory diseases, arthritis, cancer, mental illness, pregnancy complications etc. So. it became our main focused objective to “BRING BACK OMEGA-3 FATTY ACID INTO FOOD CHAIN” and develop strategies to decrease omega 6 fatty acid into food chain.

To address this genuine problem, unprecedented increase in non-communicable disease (NCD) menace, facing the nation, we, at BVDU initiated a program to unleash the power of linseed through unique innovative “FLAX BIOVILLAGE” concept. We developed “ALVEL Omega-3 egg” which received coveted Lockheed Martin Department of Science and Technology,gold medal. In order to implement our Flax Bio-village concept at national level, we got the help of World Bank assisted National Agricultural Innovation Project (NAIP)in partnership with Panjabrao Deshmukh Krishi Vidyapeeth and BAIF. First project was for backward integration with the linseed growing farmers and the second was for forward linkage with the consumer. In recognition of this pioneering effort of BVDU (2007-2014), BVDU was rewarded with ICAR, Linseed Value Addition Centre. BVDU formed “Real World Nutrition Laboratory Foundation”, to continue the backward linkage with the farmers and forward linkage with the consumer. For backward integration, a linseed growing farmers association called: “Gajanan Maharaj Javas Utpadak Gat Samuha” was formed at chikhalapur/ Umred, Chandrapur. In order to earnestly continue the research and development activities,“Centre of Innovation in Nutrition Health Disease (CINHD)” was instituted within IRSHA.

With the help of National Agricultural ScienceProject (NASF) in collaboration with NCL and Nimbalkar Agricultural Institute (NARI), we have developed high oleic (to lower inflammatory linoleic acid) which will be released by ICAR in couple of years.

At RWNLF, various omega-3 enriched products, Alvel Omega-3 egg, omega-3 oil, emulsion enriched feed mix, omega-3 enriched low GI atta mix, omega-3 soft gel capsule, researched and developed by CINHD are being test marketed and consumer acceptability is validated.

All the products being developed and validated by CINHD and ICAR. Linseed Value Addition Centre, are test marketed for ascertaining consumer acceptability at RWNLF, before undertaking large scale production with the established commercial establishments.

Research Experience

Duration Institution Particulars of work done
2012 onwards Director, Centre for Innovation in Nutrition Health Disease, Interactive Research School for Health Affairs (IRSHA) Converting ideas into innovation in Nutrition Health Disease
2000 onwards Scientific Advisor, Interactive Research School for Health Affairs, BV (DU) Converting ideas in nutrition into innovation for managing health and disease
1995-2000 Project Coordinator, National Chemical Laboratory, Pune Conducting research on omega-3 fatty acids and antioxidants in psychiatric diseases
1960-1994 Retired as Professor and Head of the Department Biochemistry Division, Department of Chemistry, University of Pune Guiding and teaching postgraduate courses in M.Sc, M.Phil, Ph.D. in Biochemistry
June 85 - Sept 85 Visiting Investigator, Sloan Kettering Cancer Centre, New York, USA Semliki Forest Virus RNA dependent RNA polymerase
Jan. 82 - May 83 Research Associate, Albert Einstein College of Medicine, New York, USA Molecular biology of Yeast Maltase Recombinant DNA technology, DNA sequencing
March 80 - Dec 81 Visiting Investigator, Sloan Kettering Cancer Center, New York, USA Replication of Semliki forest virus Animal tissue culture
March 75 - April 75 Bhabha Atomic Research Center, Mumbai Radioisotope methodology
March 62 - April 62 UGC Fellow, Indian Institute of Science, Bangalore Modern Techniques in Biochemistry

Projects

S. No. Name of the project Funding Agency Status Amount Sanctioned
1 Honey as a base for antioxidants in Health foods Directorate of Science & Technology KVIC, Mumbai Completed 4.95 Lakhs
2 Egg for health in collaboration Venkateshwara Hatchery Department of Biotechnology Completed 17 Lakhs
3 New approach to quick biogas production DST.KVIC Completed 4.9 Lakhs
4 Sustainable Rural Livelihood Security in Backward Districts of Maharashtra ICAR-NAIP III Completed 235.04 Lakhs
5 A Value Chain on Linseed: Processing and Value Addition for Profitability - Production to Consumption System (PCS) ICAR-NAIP II Completed 87.16 Lakhs
6 Developing high oleic safflower genotypes through functional genomics ICAR-NASF Completed 46.44 Lakhs (190 lakh)
7 Direct beta thalassemia carrier detection kit DBT-BIRAC Completed 44.64 Lakhs
8 Evaluation of efficacy of novel stabilized omega-3-fatty acid and antioxidants formulation for the prevention and treatment of metabolic syndrome DST-SERB Completed 40.36 Lakhs
9 ICAR-AICRP-Linseed Value Addition Centre ICAR Ongoing 101.08 Lakhs

Area of Interest

  • Role of Nutrition in Human Health and Disease
  • Flax Bio-village concept validation and commercialization omega-3 enriched products
  • Omega-3 fatty acid Nutritional Security

Honors/Awards

  • Fellowship of Society of Agricultural Biochemists 2016
    • For the last 17 years devoted and fully committed to “Omega-3 nutritional security”, through: “Flax agriculture- post harvest technology for human health and IQ”
    • The best poster award CSIR, India, (for experimental nutrition) for the work on “Maternal supplementation of fish oil at marginal protein levels influences brain fatty acid levels in Wistar rats” S Joshi, S, Rao, A, Kale, M Hegde, at XXXVI annual meeting of the Nutrition Society of India at Mysore, Nov. 2005.
    • 1st prize for the poster presentation entitled “Influence of Seed development, germination and genotypes on omega-3-ALA content in flax”. GKVK, Bangalore, Jan 2006.
    • 1st prize for the poster entitled “Flax oil stabilization for preparation of omega-3 enriched food products” Shaheeda Khan, Ulhas Wagh and Mahabaleshwar Hegde at the International Conference tenth convention of Agricultural Biochemists, on “Post-Harvest technology and value addition in cereals, pulses and oil seeds” at CS Azad University of Agriculture and Technology, Kanpur. Nov 2006.
    • Best paper award at the First annual Conference of Association of Avian Health Professionals Feb 3-4 2012, Hyderabad
    • Best paper award “Estrogenic and embryo-fetotoxic effects of ethanol extract of Linumusitatissimum in rats” at International Conference natural Products Chidambaram 2008.
    • Best research Publication Award (Ayurvet) for the year 2010, at Indian Poultry Science Association, Annual meeting held at Patna 2012.
    • Best oral presentation award at the first Annual Conference of Association of Avian Health Professionals and International Symposium 2012 at Project Directorate on Poultry Hyderabad
    • Gold medal of DST-Lockheed Martin at India Innovation Growth Programme 2013. Dr. M. V. Hegde, on 2nd May 2013.
    • Gold medal of DST-Lockheed Martin at India Innovation Growth Programme 2013. Dr. M. V. Hegde, on 2nd May 2013.
    • Sevagaurav Award by BV (DU), Dr. M. V. Hegde, on 10th May 2013
    • Special Award by BV (DU) Dr. S. S. Bhalerao, on 9th May 2013.
    • Dr. P. D. Sethi Best Research papers Awarded to the research paper “Quantification of major bioactive withanolides in Withaniasomnifera (Ashwagandha) roots by HPTLC for rapid validation of Ayurvedic products” JPC-Modern TLC, 25, 290-294. Devkar ST, Badhe YS, Jagtap SD, Hegde MV, 2012. Awarded by “ANCHROM Enterprises”.
    • 1 Lakh cash award from DST-Lockheed Martin at India Innovation Growth Programme, Patna 2013. Dr. M. V. Hegde, on 5th Dec. 2013.
    • 1 Lakh cash award from DST-Lockheed Martin at India Innovation Growth Programme, Patna 2013. Dr. S. S. Bhalerao, on 5th Dec. 2013.

Other Activities

In order to commercialize the innovations at CINHD .IRSHA, we have formed a not for profit company, Real World Nutrition Laboratory Foundation, Pune. As founder Director of this company I oversee all the activities of this company located within the premises of BV (DU).

Fellowship awarded

Society of Agricultural Biochemists FSAB

Society of Maharashtra Association of Sciences FSMAS

Professional Memberships

  • Society of Biological chemistry
  • Society of Microbiology
  • Indian Poultry Scientist Association
  • Society of Agricultural Biochemists
  • Society of Nuclear chemistry

Publications

  • International publications: 88
  • Book chapters: 14
  • Edited book by Faculty: 04
  • Patent applications: 07
  • Patent granted

Publication

Expertise in Enzymology

  • Sane, A. S., Hegde, M. V., & Joshi, P. N. (1979). Resolution of enzymes that hydrolyse phosphate esters from agave cantala on amberlite IR-120 (Al3+). Journal of Chromatography A, 168(2), 495-499.
  • Hegde, M. V., Roy, F., & Joshi, P. N. (1979). A New Method for the Preparation of β-Amylase from Sweet Potato. Preparative Biochemistry, 9(1), 71-84.
  • Roy, F., & Hegde, M. V. (1985). Rapid procedure for purification of β-amylase from Ipomea batata. Journal of Chromatography A, 324, 489-494.
  • Nehete, P. N., Hegde, M. V., Gurucharan Reddy, L., & Shankar, V. (1987). Immobilization of amyloglucosidase on polystyrene anion exchange resin II. Kinetics and stabilities. Biotechnology letters, 9(9), 651-654.
  • Roy, F., & Hegde, M. V. (1987). Immobilization of β-amylase on polystyrene cation exchange resin equilibrated with Al3+ ions (IR-120 Al3+). Enzyme and microbial technology, 9(9), 550-552.
  • Shah, N., Shah, N., Upadhyay, C., Nehete, P., Kothari, R., Hegde, M. (1989). An economically upgraded stabilized and efficient preparation of amylogycosidase. Journal of Biotechnology,10,267-276.
  • Karyekar, S. K., & Hegde, M. V. (1989). Affinity purification of penicillin acylase on phenylacetic acid linked to Indion 48-R: effect of spacer variation. Biotechnology techniques, 3(3), 145-148.
  • Shah, N. K., Upadhyay, C. M., Nehete, P. N., Kothari, R. M., & Hegde, M. V. (1990). An economical, upgraded, stabilized and efficient preparation of α-amylase. Journal of biotechnology, 16(1-2), 97-108.
  • Pathak, S. U., Karyekar, S. K., Ghole, V. S., & Hegde, M. V. (1992). Effect of activation methods on affinity chromatography of potato polyphenol oxidase. Phytochemistry, 31(5), 1481-1483.
  • Karyekar, S. K., & Hegde, M. V. (1991). The hydrophobic domain of penicillin acylase is negatively charged. Enzyme and microbial technology, 13(2), 139-141.
  • Mali, A. V., Bhise, S. S., Hegde, M. V., & Katyare, S. S. (2016). Altered erythrocyte glycolytic enzyme activities in type-II diabetes. Indian Journal of Clinical Biochemistry, 31(3), 321-325.
  • Mali, A. V., Bhise, S. S., Katyare, S. S., & Hegde, M. V. (2018). Altered kinetics properties of erythrocyte lactate dehydrogenase in type II diabetic patients and its implications for lactic acidosis. Indian Journal of Clinical Biochemistry, 33(1), 38-45.
  • Bhise, S. S., Rao, J. R., Hegde, M. V., & Katyare, S. S. (2020). Compositional alterations in erythrocyte membranes in Type II diabetes. Indian Journal of Experimental Biology (IJEB), 58(10), 671-679.
  • Bhise, S., Rao, J., Hegde, M., & Katyare, S. (2020). Type 2 diabetes differentially affects the substrate saturation kinetic attributes of erythrocyte hexokinase and phosphofructokinase. FEBS letters, 594(2), 240-250.

Expertise in Molecular Biology

  • Chow, T., Goldenthal, M. J., Cohen, J. D., Hegde, M., & Marmur, J. (1983). Identification and physical characterization of yeast maltase structural genes. Molecular and General Genetics MGG, 191(3), 366-371.
  • Basu, M., Hegde, M. V., & Modak, M. J. (1983). Synthesis of compositionally unique DNA by terminal deoxynucleotidyltransferase. Biochemical and biophysical research communications, 111(3), 1105-1112.
  • Chow, T., Goldenthal, M. J., Cohen, J. D., Hegde, M., & Marmur, J. (1983). Identification and physical characterization of yeast maltase structural genes. Molecular and General Genetics MGG, 191(3), 366-371.
  • Nayak, A. R., Nair, J. S., Hegde, M. V., Ranjekar, P. K., & Pant, U. (1991). Genome analysis of two mosquito species. Insect biochemistry, 21(7), 803-808.
  • Bankar, M. P., Kate, S. L., Ranade, S. A., Barnabas, R. J., Mokashi, G. D., Phadke, M. A., & Hegde, M. V. (1993). Prenatal diagnosis of sickle cell anemia using polymerase chain reaction. Indian pediatrics, 30(11), 1340-1343.
  • Phadke, M. A., Barnabas, R., Bhate, S. M., Gambhir, P. S., Kate, S. L., & Hegde, M. V. (1996). Hb-pune: A new gamma beta crossover hemoglobin from an Indian family. INTERNATIONAL JOURNAL OF PEDIATRIC HEMATOLOGY/ONCOLOGY, 3(2), 147-151.

Expertise in Brain Health

  • Ranjekar, P. K., Hinge, A., Hegde, M. V., Ghate, M., Kale, A., Sitasawad, S., ... & Mahadik, S. P. (2003). Decreased antioxidant enzymes and membrane essential polyunsaturated fatty acids in schizophrenic and bipolar mood disorder patients. Psychiatry research, 121(2), 109-122.
  • Hegde, M. V., & Saraph, A. A. (2011). Unstable genes unstable mind: beyond the central dogma of molecular biology. Medical Hypotheses, 77(2), 165-170.
  • Kasote, D. M., Hegde, M. V., & Katyare, S. S. (2013). Mitochondrial dysfunction in psychiatric and neurological diseases: cause(s), consequence(s), and implications of antioxidant therapy. Biofactors, 39(4), 392-406.

    Expertise in Omega-3 fatty acid

  • Joshi, S., Rao, S., Girigosavi, S., Daware, M., Kale, A., &Hegde, M. (2004). Differential effects of fish oil and folic acid supplementation during pregnancy in rats on cognitive performance and serum glucose in their offspring. Nutrition, 20(5), 465-472.
  • Rao, S., Joshi, S., Kale, A., Hegde, M., &Mahadik, S. (2006). Maternal folic acid supplementation to dams on marginal protein level alters brain fatty acid levels of their adult offspring. Metabolism, 55(5), 628-634.
  • Bhalerao, S., Hegde, M., Kadam, S. (2011). Omega-3, Omega-6 fatty acids in human health and disease, Bharati Vidyapeeth (Deemed to be University) Journal 11, 3-9.
  •  Badhe, Y., Kukade, D., Gosavi, T., Karandikar, M., Hegde, M. (2013). Significance of fatty acid analysis in lipid profile. Bharati Vidyapeeth (Deemed to be University) research journal, Volume number 3, 5-15
  • Jagtap, A. A., Badhe, Y. S., Farde, P. D., Hegde, M. V., &Zanwar, A. A. (2021). Long-term Storage Stability Assessment of Omega-3-Fatty Acid Emulsified Formulation Containing Micronutrients. Journal of Pharmaceutical Innovation, 1-10.
  • Jagtap, A. A., Badhe, Y. S., Hegde, M. V., &Zanwar, A. A. (2021). Development and characterization of stabilized omega-3 fatty acid and micronutrient emulsion formulation for food fortification. Journal of Food Science and Technology, 58(3), 996-1004.
  • Joshi, A., Hegde, M., &Zanwar, A. (2022). Flaxseed oil and palm olein blend to improve omega-6: Omega-3 ratio. Journal of Food Science and Technology, 59(2), 498-509.

          Expertise in Phyto nutrients

  • Hegde, M. V., Patil, S., &Bhalerao, S. (2008). A philosophy for integration of ayurveda with modern medicine: A biochemist's perspective. Current science, 95(6), 721-722.
  • Kasote, D. M., Hegde, M. V., &Deshmukh, K. K. (2011). Antioxidant activity of phenolic components from n-butanol fraction (PC-BF) of defatted flaxseed meal. Am J Food Technol, 6(7), 604-612.
  • Kasote D M, Hegde M.V. Deshmukh K. K. (2011). HPTLC and LC-ESI-MS characterization of ether insoluble phenolic components from n-butanol fraction (EPC-BF) of defatted flaxseed meal. Int. J. Drug Dev. & Res, 3(3), 126-130.
  • Kasote, D. M., Zanwar, A. A., Devkar, S. T., Hegde, M. V., &Deshmukh, K. K. (2012). Immunomodulatory activity of ether insoluble phenolic components of n-butanol fraction (EPC-BF) of flaxseed in rat. Asian Pacific Journal of Tropical Biomedicine, 2(2), S623-S626.
  •  Kasote, D. M., Badhe, Y. S., &Hegde, M. V. (2013). Effect of mechanical press oil extraction processing on quality of linseed oil. Industrial Crops and Products, 42, 10-13.
  • Kasote, D. M., Pawar, N. M., Sadgir, S. K., Bharati, K. T., Jagtap, S. D., &Hegde, M. V. (2013). Antioxidant and collagenase inhibitory activity of ether soluble phenolic components of n-butanol fraction (ESP-BF) of flaxseed. International Food Research Journal, 20(6), 3133.
  • Kasote, D. M., Katyare, S. S., Hegde, M. V., &Bae, H. (2015). Significance of antioxidant potential of plants and its relevance to therapeutic applications. International journal of biological sciences, 11(8), 982.
  • Honmore, V. S., Kandhare, A. D., Kadam, P. P., Khedkar, V. M., Sarkar, D., Bodhankar, S. L., ... &Natu, A. D. (2016). Isolates of AlpiniaofficinarumHance as COX-2 inhibitors: Evidence from anti-inflammatory, antioxidant and molecular docking studies. International immunopharmacology, 33, 8-17.
  •  Hegde, M. (2019). Unleashing the Power of Linseed to Improve Public Health and Combat Non-Communicable Disease Menace in the Country. Indian Journal of Agricultural Biochemistry, 32(1), 1-9.
  • Kasote, D. M., Badhe, Y. S., Zanwar, A. A., Hegde, M. V., &Deshmukh, K. K. (2012). Hepatoprotective potential of ether insoluble phenolic components of n-butanol fraction (EPC-BF) of flaxseed against CCl4-induced liver damage in rats. Journal of pharmacy &bioallied sciences, 4(3), 231.
  •  Kasote, D. M., Hegde, M. V., &Katyare, S. S. (2013). Mitochondrial dysfunction in psychiatric and neurological diseases: cause (s), consequence (s), and implications of antioxidant therapy. Biofactors, 39(4), 392-406.
  •  Zanwar, A. A., Hegde, M. V., &Bodhankar, S. L. (2010). In vitro antioxidant activity of ethanolic extract of Linumusitatissimum. Pharmacologyonline, 1, 683-696.
  •  Zanwar, A. A., Aswar, U. M., Hegde, M. V., &Bodhankar, S. L. (2010). Estrogenic and embryo-fetotoxic effects of ethanol extract of Linumusitatissimum in rats. Journal of Complementary and Integrative Medicine, 7(1).
  • Zanwar, A. A., Hegde, M. V., &Bodhankar, S. L. (2012). Antihyperlipidemic effect of flax lignan concentrate in triton induced hyperlipidemic rats. International Journal of Pharmacology, 8(5), 355-363.
  •  Zanwar, A. A., Hegde, M. V., &Bodhankar, S. L. (2013). Protective role of concomitant administration of flax lignan concentrate and omega-3-fatty acid on myocardial damage in doxorubicin-induced cardiotoxicity. Food Science and Human Wellness, 2(1), 29-38
  • Zanwar, A. A., Hegde, M. V., Rojatkar, S. R., &Bodhankar, S. L. (2014). Antihyperlipidemic activity of concomitant administration of methanolic fraction of flax lignan concentrate and omega-3-fatty acid in poloxamer-407 induced experimental hyperlipidemia. Industrial Crops and Products, 52, 656-663.
  • Zanwar, A. A., Hegde, M. V., Rojatkar, S. R., Sonawane, K. B., Rajamohanan, P. R., & Bodhankar, S. L. (2014). Isolation, characterization and antihyperlipidemic activity of secoisolariciresinoldiglucoside in poloxamer-407-induced experimental hyperlipidemia. Pharmaceutical Biology, 52(9), 1094-1103.
  • Mali, A. V., Wagh, U. V., Hegde, M. V., Chandorkar, S. S., Surve, S. V., &Patole, M. V. (2012). In vitro anti-metastatic activity of enterolactone, a mammalian lignan derived from flax lignan, and down-regulation of matrix metalloproteinases in MCF-7 and MDA MB 231 cell lines. Indian journal of cancer, 49(1), 181.
  •  Mali, A. V., Joshi, A. A., Hegde, M. V., &Kadam, S. S. (2017). Enterolactone suppresses proliferation, migration and metastasis of MDA-MB-231 breast cancer cells through inhibition of uPA induced plasmin activation and MMPs-mediated ECM remodeling. Asian Pacific journal of cancer prevention: APJCP, 18(4), 905
  •  Mali, A. V., Joshi, A. A., Hegde, M. V., &Kadam, S. S. (2018). Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial–mesenchymal transition. Cancer biology & medicine, 15(2), 137.
  •  Mali, A. V., Padhye, S. B., Anant, S., Hegde, M. V., &Kadam, S. S. (2019). Anticancer and antimetastatic potential of enterolactone: clinical, preclinical and mechanistic perspectives. European journal of pharmacology, 852, 107-124.
  •  Ulhe A, Sharma N, Mahajan A, Patil R, Hegde M, Bhalerao S, Mali A. (2023) Decoding the therapeutic landscape of alpha-linolenic acid: a network pharmacology and bioinformatics investigation against cancer-related epigenetic modifiers. Journal of Biomolecular Structure and Dynamics, Dec 8:1-26.
  •  Zanwar, A., Hegde, M., & Bodhankar, S. (2011). Cardioprotective activity of flax lignan concentrate extracted from seeds of in isoprenalin induced myocardial necrosis in rats. Interdisciplinary toxicology, 4(2), 90-97.
  •  Anand Zanwar, ParekarV.Nilkanth Mahabaleshwar Hegde, Subhash L Bodhankar, Effect of methanolic fraction of flax lignan concentrate against diabetic cardiopathy in streptozotocin-
  •  Anand A. Zanwar, Mahabaleshwar V. Hegde, Subhash L. Bodhankar Ethanolic extract of seeds of Linum ussitattimum (flax lignan concentrate) prevents doxorubicin-induced cardiotoxicity in rats Atherosclerosis Supplements12(1)1462011-38
  • Devkar, S., Badhe, Y., Jagtap, S., &Hegde, M. (2012). Quantification of major bioactive withanolides in Withaniasomnifera (Ashwagandha) roots by HPTLC for rapid validation of Ayurvedic products. JPC-Journal of Planar Chromatography-Modern TLC, 25(4), 290-294.
  • . Devkar, S. T., Jagtap, S. D., Katyare, S. S., &Hegde, M. V. (2014). Estimation of Antioxidant Potential of Individual Components Present in Complex Mixture of Withaniasomnifera (Ashwagandha) Root Fraction by Thin-Layer Chromatography—2, 2-Diphenyl-1-Picrylhdrazyl Method. JPC–Journal of Planar Chromatography–Modern TLC, 27(3), 157-161
  •  Gosavi, T. P., Kumar, V. S., Kandhare, A. D., Zanwar, A. A., Hegde, M. V., &Bodhankar, S. L. (2014). A comprehensive metaanalysis and systematic review on effect of genistein on metabolic syndrome. Pharmacologia, 5, 120-126.
  •  Devkar, S. T., Suryapujary, S. M., Jagtap, S. D., Katyare, S. S., &Hegde, M. V. (2015). Effect of macronutrient deficiency on withanolides content in the roots of Withaniasomnifera and its correlationship with molybdenum content. Pharmaceutical Biology, 53(4), 518-523.
  • . Devkar, S. T., Kandhare, A. D., Sloley, B. D., Jagtap, S. D., Lin, J., Tam, Y. K., ... &Hegde, M. V. (2015). Evaluation of the bioavailability of major withanolides of Withaniasomnifera using an in vitro absorption model system. Journal of advanced pharmaceutical technology & research, 6(4), 159.
  • Devkar, S. T., Kandhare, A. D., Zanwar, A. A., Jagtap, S. D., Katyare, S. S., Bodhankar, S. L., &Hegde, M. V. (2016). Hepatoprotective effect of withanolide-rich fraction in acetaminophen-intoxicated rat: decisive role of TNF-α, IL-1β, COX-II and iNOS. Pharmaceutical Biology, 54(11), 2394-2403.

Expertise in Cancer

  • Hegde, M. V., Mali, A. V., &Chandorkar, S. S. (2013). What is a cancer cell? Why does it metastasize?Asian Pacific Journal of Cancer Prevention, 14(6), 3987-3989
  • Mahabaleshwar, H., Nupur, H., Revati, D., Garish, G., &Shahida, K. (2010). Oral precancerous lesions show increased levels of glutathione compared to cancerous tissue. Current Nutrition & Food Science, 6(3), 223-226.
  • Suryavanshi, S., Zanwar, A., Hegde, M., &Kaul-Ghanekar, R. (2014). Standardization of a polyherbal formulation (HC9) and comparative analysis of its cytotoxic activity with the individual herbs present in the composition in breast cancer cell lines. Pharmacognosy Journal, 6(2).
  • Mali, A. V., Joshi, A. A., Hegde, M. V., &Kadam, S. S. (2017). Enterolactone suppresses proliferation, migration and metastasis of MDA-MB-231 breast cancer cells through inhibition of uPA induced plasmin activation and MMPs-mediated ECM remodeling. Asian Pacific journal of cancer prevention: APJCP, 18(4), 905
  • Ulhe A, Sharma N, Mahajan A, Patil R, Hegde M, Bhalerao S, Mali A. (2023) Decoding the therapeutic landscape of alpha-linolenic acid: a network pharmacology and bioinformatics investigation against cancer-related epigenetic modifiers. Journal of Biomolecular Structure and Dynamics, Dec 8:1-26.

  • Liver Disease

    • Krishna, K., B Pradhan, A., V Hegde, M., A Zanwar, A., I Pathan, S., Patil, A., & A Khan, S. (2010). Can Progression of Alcoholic Liver Disease be Predicted from Certain Biochemical Indices? Current Nutrition & Food Science, 6(3), 204-208.
    • Kasote, D. M., Badhe, Y. S., Zanwar, A. A., Hegde, M. V., &Deshmukh, K. K. (2012). Hepatoprotective potential of ether insoluble phenolic components of n-butanol fraction (EPC-BF) of flaxseed against CCl4-induced liver damage in rats. Journal of pharmacy &bioallied sciences, 4(3), 231.

    Poultry Science

    • Bhalerao, S., Hegde, M., Ranad, A., Nikam, S., Kshirsagar, K., &Kadam, S. (2010). Studies in the production of Omega 3 enriched chicken meat: II. Indian Journal of Poultry Science, 45(3), 273-279.
    • Bhalerao, S., Hegde, M., Ranade, A., Desai, D., &Kadam, S. (2011). Studies in the production of Omega 3 enriched chicken meat: 1. Indian Journal of Poultry Science, 46(1), 40-45
    • Bhalerao, S., Hegde, M., Atkare, S., Gondchar, D., Jadhav, R., Kadam, S. (2011). Rural employment through omega-3 chicken production by resourcing linseed as a source of omega-3 fatty acids, J Bombay Vet Coll. 19, 26-29.
    • Bhalerao, S., Hegde, M., Katyare, S., &Kadam, S. (2014). Promotion of omega-3 chicken meat production: an Indian perspective. World's Poultry Science Journal, 70(2), 365-374.
    • Bhalerao, S., Hegde, M., Kadam, S. (2011). Omega-3, Omega-6 fatty acids in human health and disease, Bharati Vidyapeeth (Deemed to be University) Journal 11, 3-9.
    • Mahabaleshwar V. Hegde, Anand A. Zanwar, Shahida A. Khan, Ulhas V. Wagh.Omega-3 fatty acid enriched eggs are heart friendly Atherosclerosis Supplements12(1)1482011 Wound Healing
    • Goswami, S., Kandhare, A., Zanwar, A. A., Hegde, M. V., Bodhankar, S. L., Shinde, S., ... &Kharat, R. (2016). Oral l-glutamine administration attenuated cutaneous wound healing in Wistar rats. International wound journal, 13(1), 116-124.

    Wound Healing

    • Badhe, Y., Kukade, D., Gosavi, T., Karandikar, M., Hegde, M. (2013). Significance of fatty acid analysis in lipid profile. Bharati Vidyapeeth (Deemed to be University) research journal, Volume number 3, 5-15.

    Fatty acid Analysis

    • Badhe, Y., Kukade, D., Gosavi, T., Karandikar, M., Hegde, M. (2013). Significance of fatty acid analysis in lipid profile. Bharati Vidyapeeth (Deemed to be University) research journal, Volume number 3, 5-15.

    Diabetes

    • Mali, A. V., Bhise, S. S., Hegde, M. V., &Katyare, S. S. (2016). Altered erythrocyte glycolytic enzyme activities in type-II diabetes. Indian Journal of Clinical Biochemistry, 31(3), 321-325
    • Mali, A. V., Bhise, S. S., Katyare, S. S., &Hegde, M. V. (2018). Altered kinetics properties of erythrocyte lactate dehydrogenase in type II diabetic patients and its implications for lactic acidosis. Indian Journal of Clinical Biochemistry, 33(1), 38-45.
    • Bhise, S. S., Rao, J. R., Hegde, M. V., &Katyare, S. S. (2020). Compositional alterations in erythrocyte membranes in Type II diabetes. Indian Journal of Experimental Biology (IJEB), 58(10), 671-679.
    • Bhise, S., Rao, J., Hegde, M., &Katyare, S. (2020). Type 2 diabetes differentially affects the substrate saturation kinetic attributes of erythrocyte hexokinase and phosphofructokinase. FEBS letters, 594(2), 240-250.
    • Anand A. Zanwar, Asavari A. Joshi, Prajakta S. Gaikwad, Mahabaleshwar V. Hegde (2024) Type 3 Diabetes Mellitus, Insulin Resistance, Alzheimer, and Role of Alpha-Linolenic Acid in Blood–Brain Barrier Repair, CDRP, Chronicle of Diabetes Research and Practice (In Press)

    Omega-3 fortifier

    • Jagtap, A. A., Badhe, Y. S., Farde, P. D., Hegde, M. V., &Zanwar, A. A. (2021). Long-term Storage Stability Assessment of Omega-3-Fatty Acid Emulsified Formulation Containing micronutrients. Journal of Pharmaceutical Innovation, 1-10.
    • Jagtap, A. A., Badhe, Y. S., Hegde, M. V., &Zanwar, A. A. (2021). Development and characterization of stabilized omega-3 fatty acid and micronutrient emulsion formulation for food fortification. Journal of Food Science and Technology, 58(3), 996-1004.
    • Jagtap AA, Joshi AA, Badhe YS, Farde PD, Hegde MV, Zanwar AA. Bioavailability of Omega-3 Fatty Acid In Normal and High Fat High Carbohydrate Diet Induced Animal Model. Metabolism-Clinical and Experimental. 2021 Mar 1;116.

    Rheumatoid Arthritis

    • Bhat CH, DFarde PR, Vedpathak SM, Hegde MV, ZanwarAA. Efficacy of omega-3-enriched medicated massage oil in Rheumatoid Arthritis: Efficacy of omega-3-enriched medicated massage oil in Rheumatoid Arthritis. Journal of Oilseeds Research.;37(Specialissue).

    Edible oil

    • Joshi, A., Hegde, M., &Zanwar, A. (2022). Flaxseed oil and palm olein blend to improve omega-6: Omega-3 ratio. Journal of Food Science and Technology, 59(2), 498-509.
    • Joshi AA, Hegde MV, Zanwar AA. Modulation of essential fatty acid levels in coconut oil with flaxseed oil. Grasas y Aceites. 2023 Jun 13;74(2):e503.
    • Farde PR, Hegde MV, Zanwar AA. Blending of linseed oil with edible oil to improve nutritional quality of edible oil blends. Indian Society of Oilseeds Research.;2021:256.
    •  

     

    Patent applications:

    • Mahabaleshwar. Hegde, UlhasWagh and Shahida Khan, Omega-3 Fatty acid compositions with honey, World Patent, PCT/IN05/00163 dated 24.05.2005.
    • MahabaleshwarHegde, SurekhaBhalerao, ShivajiraoKadam, Indian patent application No 1971/MUM/2012-Composition for chicken feed for production of Omega-3 Chicken and method thereof. Date of filling: 9-Jul-12, Publication date (U/S 11A)-07-02-2014.
    • Mahabaleshwar V Hegde, Surekha S. Bhalerao, “Omega-3 supplement feed composition for omega -3 eggs production” Indian Patent Application No. 2193/MUM/2014 dated 7-Jul-14.
    • Mahabaleshwar. Hegde, Ulhas Wagh. Nutritional and rejuvenative food supplement capable of fortifying any food products. Application Number 1717/MUM/2012. Publication date (U/S 11A)-14/02/2014
    • Mahabaleshwar Hegde, Anand A. Zanwar, Subhash L. Bodhankar, TejasGosavi, Yogesh S. Badhe. Fortified omega-3 ghee and process for preparation thereof. Indian Full Patent Application-3719/MUM/2013. Publication date (U/S 11A)- 27/12/2013.
    • Shanta Modak, Chathuranga De Silva, Arnabkumar Ghosh, Anand Zanwar, Mahabaleshwar Hegde. Polymer films with antimicrobial agents. International Patent Application No. PCT/US18/44247 WO2019/023685Al. 27/07/2018
    • Shanta Modak,ArnabKumar Ghosh, Chathuranga C. De Silva, Mahabaleshwar Hegde, Anand Zanwar, Santoshkumar Dongre, Shivajirao S. Kadam. Coatings and methods for infection-resistant medical devices. US Provisional Patent Application no. 62333905. Priority date-10-05-2016.

    Books

    • "Biochemistry for undergraduate "M.V.Hegde, A.M.Diwan and M.V. Athavale. NarendraPrakashan (1978).
    • A course in Industrial Chemistry" part I: A chapter on Sugar Industries: N.R.Ayyengar, M.V.Hegde, A.J.Mukhedkar, N.S.Narasimhan, P.G.Pol and A.C.Ranade. Orient Longman (1977).
    • "A course in Industrial Chemistry" part II : A chapter on Fermentation Industries : M.V.Hegde, S.B.Kulkarni, A.J.Mukhedkar, P.G.Pol and D.L. Roy. Orient Longman (1978).
    • Mahabaleshwar V. Hegde, Anand A. Zanwar, Sharad P. Adekar. Omega-3 Fatty Acids - Keys to Nutritional Health 2016. Humana Press Springer Science. Springer International Publishing Switzerland. DOI: 10.1007/978-3-319-40458-5. ISBN: 978-3-319-40456-1 (Print) 978-3-319-40458-5 (Online).

      Books chapters

        • Hegde, M. V., Patil, S., & Bhalerao, S. (2008). A philosophy for integration of ayurveda with modern medicine: A biochemist's perspective. Current science, 95(6), 721-722.
        • Kasote, D. M., Hegde, M. V., & Deshmukh, K. K. (2011). Antioxidant activity of phenolic components from n-butanol fraction (PC-BF) of defatted flaxseed meal. Am J Food Technol, 6(7), 604-612.
        • Kasote D M, Hegde M.V. Deshmukh K. K. (2011). HPTLC and LC-ESI-MS characterization of ether insoluble phenolic components from n-butanol fraction (EPC-BF) of defatted flaxseed meal. Int. J. Drug Dev. & Res, 3(3), 126-130.
        • Kasote, D. M., Zanwar, A. A., Devkar, S. T., Hegde, M. V., & Deshmukh, K. K. (2012). Immunomodulatory activity of ether insoluble phenolic components of n-butanol fraction (EPC-BF) of flaxseed in rat. Asian Pacific Journal of Tropical Biomedicine, 2(2), S623-S626.
        • Kasote, D. M., Badhe, Y. S., & Hegde, M. V. (2013). Effect of mechanical press oil extraction processing on quality of linseed oil. Industrial Crops and Products, 42, 10-13.
        • Kasote, D. M., Pawar, N. M., Sadgir, S. K., Bharati, K. T., Jagtap, S. D., & Hegde, M. V. (2013). Antioxidant and collagenase inhibitory activity of ether soluble phenolic components of n-butanol fraction (ESP-BF) of flaxseed. International Food Research Journal, 20(6), 3133.
        • Kasote, D. M., Katyare, S. S., Hegde, M. V., & Bae, H. (2015). Significance of antioxidant potential of plants and its relevance to therapeutic applications. International journal of biological sciences, 11(8), 982.
        • Honmore, V. S., Kandhare, A. D., Kadam, P. P., Khedkar, V. M., Sarkar, D., Bodhankar, S. L., ... & Natu, A. D. (2016). Isolates of AlpiniaofficinarumHance as COX-2 inhibitors: Evidence from anti-inflammatory, antioxidant and molecular docking studies. International immunopharmacology, 33, 8-17.
        • Hegde, M. (2019). Unleashing the Power of Linseed to Improve Public Health and Combat Non-Communicable Disease Menace in the Country. Indian Journal of Agricultural Biochemistry, 32(1), 1-9.
        • Kasote, D. M., Badhe, Y. S., Zanwar, A. A., Hegde, M. V., & Deshmukh, K. K. (2012). Hepatoprotective potential of ether insoluble phenolic components of n-butanol fraction (EPC-BF) of flaxseed against CCl4-induced liver damage in rats. Journal of pharmacy & bioallied sciences, 4(3), 231.
        • Kasote, D. M., Hegde, M. V., & Katyare, S. S. (2013). Mitochondrial dysfunction in psychiatric and neurological diseases: cause (s), consequence (s), and implications of antioxidant therapy. Biofactors, 39(4), 392-406.
        • Hegde, M. V., Patil, S., & Bhalerao, S. (2008). A philosophy for integration of ayurveda with modern medicine: A biochemist's perspective. Current science, 95(6), 721-722.
        • Kasote, D. M., Hegde, M. V., & Deshmukh, K. K. (2011). Antioxidant activity of phenolic components from n-butanol fraction (PC-BF) of defatted flaxseed meal. Am J Food Technol, 6(7), 604-612.
        • Kasote D M, Hegde M.V. Deshmukh K. K. (2011). HPTLC and LC-ESI-MS characterization of ether insoluble phenolic components from n-butanol fraction (EPC-BF) of defatted flaxseed meal. Int. J. Drug Dev. & Res, 3(3), 126-130.
        • Kasote, D. M., Zanwar, A. A., Devkar, S. T., Hegde, M. V., & Deshmukh, K. K. (2012). Immunomodulatory activity of ether insoluble phenolic components of n-butanol fraction (EPC-BF) of flaxseed in rat. Asian Pacific Journal of Tropical Biomedicine, 2(2), S623-S626.
        • Kasote, D. M., Badhe, Y. S., & Hegde, M. V. (2013). Effect of mechanical press oil extraction processing on quality of linseed oil. Industrial Crops and Products, 42, 10-13.
        • Kasote, D. M., Pawar, N. M., Sadgir, S. K., Bharati, K. T., Jagtap, S. D., & Hegde, M. V. (2013). Antioxidant and collagenase inhibitory activity of ether soluble phenolic components of n-butanol fraction (ESP-BF) of flaxseed. International Food Research Journal, 20(6), 3133.
        • Kasote, D. M., Katyare, S. S., Hegde, M. V., & Bae, H. (2015). Significance of antioxidant potential of plants and its relevance to therapeutic applications. International journal of biological sciences, 11(8), 982.
        • Honmore, V. S., Kandhare, A. D., Kadam, P. P., Khedkar, V. M., Sarkar, D., Bodhankar, S. L., ... & Natu, A. D. (2016). Isolates of AlpiniaofficinarumHance as COX-2 inhibitors: Evidence from anti-inflammatory, antioxidant and molecular docking studies. International immunopharmacology, 33, 8-17.
        • Hegde, M. (2019). Unleashing the Power of Linseed to Improve Public Health and Combat Non-Communicable Disease Menace in the Country. Indian Journal of Agricultural Biochemistry, 32(1), 1-9.
        • Kasote, D. M., Badhe, Y. S., Zanwar, A. A., Hegde, M. V., & Deshmukh, K. K. (2012). Hepatoprotective potential of ether insoluble phenolic components of n-butanol fraction (EPC-BF) of flaxseed against CCl4-induced liver damage in rats. Journal of pharmacy & bioallied sciences, 4(3), 231.
        • Kasote, D. M., Hegde, M. V., & Katyare, S. S. (2013). Mitochondrial dysfunction in psychiatric and neurological diseases: cause (s), consequence (s), and implications of antioxidant therapy. Biofactors, 39(4), 392-406.
        • Zanwar, A. A., Hegde, M. V., & Bodhankar, S. L. (2010). In vitro antioxidant activity of ethanolic extract of Linum usitatissimum. Pharmacologyonline, 1, 683-696.
        • Zanwar, A. A., Aswar, U. M., Hegde, M. V., & Bodhankar, S. L. (2010). Estrogenic and embryo-fetotoxic effects of ethanol extract of Linum usitatissimum in rats. Journal of Complementary and Integrative Medicine, 7(1).
        • Zanwar, A. A., Hegde, M. V., & Bodhankar, S. L. (2012). Antihyperlipidemic effect of flax lignan concentrate in triton induced hyperlipidemic rats. International Journal of Pharmacology, 8(5), 355-363.
        • Zanwar, A. A., Hegde, M. V., & Bodhankar, S. L. (2013). Protective role of concomitant administration of flax lignan concentrate and omega-3-fatty acid on myocardial damage in doxorubicin-induced cardiotoxicity. Food Science and Human Wellness, 2(1), 29-38.
        • Zanwar, A. A., Hegde, M. V., Rojatkar, S. R., & Bodhankar, S. L. (2014). Antihyperlipidemic activity of concomitant administration of methanolic fraction of flax lignan concentrate and omega-3-fatty acid in poloxamer-407 induced experimental hyperlipidemia. Industrial Crops and Products, 52, 656-663.
        • Zanwar, A. A., Hegde, M. V., Rojatkar, S. R., Sonawane, K. B., Rajamohanan, P. R., & Bodhankar, S. L. (2014). Isolation, characterization and antihyperlipidemic activity of secoisolariciresinol diglucoside in poloxamer-407-induced experimental hyperlipidemia. Pharmaceutical Biology, 52(9), 1094-1103.
        • Mali, A. V., Wagh, U. V., Hegde, M. V., Chandorkar, S. S., Surve, S. V., & Patole, M. V. (2012). In vitro anti-metastatic activity of enterolactone, a mammalian lignan derived from flax lignan, and down-regulation of matrix metalloproteinases in MCF-7 and MDA MB 231 cell lines. Indian journal of cancer, 49(1), 181.
        • Mali, A. V., Joshi, A. A., Hegde, M. V., & Kadam, S. S. (2017). Enterolactone suppresses proliferation, migration and metastasis of MDA-MB-231 breast cancer cells through inhibition of uPA induced plasmin activation and MMPs-mediated ECM remodeling. Asian Pacific journal of cancer prevention: APJCP, 18(4), 905.
        • Mali, A. V., Joshi, A. A., Hegde, M. V., & Kadam, S. S. (2018). Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial–mesenchymal transition. Cancer biology & medicine, 15(2), 137.
        • Mali, A. V., Padhye, S. B., Anant, S., Hegde, M. V., & Kadam, S. S. (2019). Anticancer and antimetastatic potential of enterolactone: clinical, preclinical and mechanistic perspectives. European journal of pharmacology, 852, 107-124.
        • Ulhe A, Sharma N, Mahajan A, Patil R, Hegde M, Bhalerao S, Mali A. (2023) Decoding the therapeutic landscape of alpha-linolenic acid: a network pharmacology and bioinformatics investigation against cancer-related epigenetic modifiers. Journal of Biomolecular Structure and Dynamics, Dec 8:1-26.
        • Zanwar, A., Hegde, M., & Bodhankar, S. (2011). Cardioprotective activity of flax lignan concentrate extracted from seeds of in isoprenalin induced myocardial necrosis in rats. Interdisciplinary toxicology, 4(2), 90-97.
        • Anand Zanwar, Parekar V. Nilkanth Mahabaleshwar Hegde, Subhash L Bodhankar, Effect of methanolic fraction of flax lignan concentrate against diabetic cardiopathy in streptozotocin-nicotinamide induced diabetic rats Journal of Atherosclerosis and Thrombosis Vol 21. Supplement 3, 2014-36.
        • Anand A. Zanwar, Mahabaleshwar V. Hegde, Subhash L. Bodhankar Ethanolic extract of seeds of Linum usitatissimum (flax lignan concentrate) prevents doxorubicin-induced cardiotoxicity in rats Atherosclerosis Supplements 12(1)1462011-38.
        • Devkar, S., Badhe, Y., Jagtap, S., & Hegde, M. (2012). Quantification of major bioactive withanolides in Withaniasomnifera (Ashwagandha) roots by HPTLC for rapid validation of Ayurvedic products. JPC-Journal of Planar Chromatography-Modern TLC, 25(4), 290-294.
        • Devkar, S. T., Jagtap, S. D., Katyare, S. S., & Hegde, M. V. (2014). Estimation of Antioxidant Potential of Individual Components Present in Complex Mixture of Withaniasomnifera (Ashwagandha) Root Fraction by Thin-Layer Chromatography—2, 2-Diphenyl-1-Picrylhdrazyl Method. JPC–Journal of Planar Chromatography–Modern TLC, 27(3), 157-161.
        • Gosavi, T. P., Kumar, V. S., Kandhare, A. D., Zanwar, A. A., Hegde, M. V., & Bodhankar, S. L. (2014). A comprehensive metaanalysis and systematic review on effect of genistein on metabolic syndrome. Pharmacologia, 5, 120-126.
        • Devkar, S. T., Suryapujary, S. M., Jagtap, S. D., Katyare, S. S., & Hegde, M. V. (2015). Effect of macronutrient deficiency on withanolides content in the roots of Withaniasomnifera and its correlationship with molybdenum content. Pharmaceutical Biology, 53(4), 518-523.
        • Devkar, S. T., Kandhare, A. D., Sloley, B. D., Jagtap, S. D., Lin, J., Tam, Y. K., ... & Hegde, M. V. (2015). Evaluation of the bioavailability of major withanolides of Withaniasomnifera using an in vitro absorption model system. Journal of advanced pharmaceutical technology & research, 6(4), 159.
        • Devkar, S. T., Kandhare, A. D., Zanwar, A. A., Jagtap, S. D., Katyare, S. S., Bodhankar, S. L., & Hegde, M. V. (2016). Hepatoprotective effect of withanolide-rich fraction in acetaminophen-intoxicated rat: decisive role of TNF-α, IL-1β, COX-II and iNOS. Pharmaceutical Biology, 54(11), 2394-2403.
        • Hegde, M. V., Mali, A. V., & Chandorkar, S. S. (2013). What is a cancer cell? Why does it metastasize? Asian Pacific Journal of Cancer Prevention, 14(6), 3987-3989.
        • Mahabaleshwar, H., Nupur, H., Revati, D., Garish, G., & Shahida, K. (2010). Oral precancerous lesions show increased levels of glutathione compared to cancerous tissue. Current Nutrition & Food Science, 6(3), 223-226.
        • Suryavanshi, S., Zanwar, A., Hegde, M., & Kaul-Ghanekar, R. (2014). Standardization of a polyherbal formulation (HC9) and comparative analysis of its cytotoxic activity with the individual herbs present in the composition in breast cancer cell lines. Pharmacognosy Journal, 6(2).
        • Mali, A. V., Joshi, A. A., Hegde, M. V., & Kadam, S. S. (2017). Enterolactone suppresses proliferation, migration and metastasis of MDA-MB-231 breast cancer cells through inhibition of uPA induced plasmin activation and MMPs-mediated ECM remodeling. Asian Pacific journal of cancer prevention: APJCP, 18(4), 905.
        • Ulhe, A., Sharma, N., Mahajan, A., Patil, R., Hegde, M., Bhalerao, S., & Mali, A. (2023). Decoding the therapeutic landscape of alpha-linolenic acid: a network pharmacology and bioinformatics investigation against cancer-related epigenetic modifiers. Journal of Biomolecular Structure and Dynamics, Dec 8:1-26.
        • Krishna, K., B Pradhan, A., V Hegde, M., A Zanwar, A., I Pathan, S., Patil, A., & A Khan, S. (2010). Can Progression of Alcoholic Liver Disease be Predicted from Certain Biochemical Indices? Current Nutrition & Food Science, 6(3), 204-208.
        • Kasote, D. M., Badhe, Y. S., Zanwar, A. A., Hegde, M. V., &Deshmukh, K. K. (2012). Hepatoprotective potential of ether insoluble phenolic components of n-butanol fraction (EPC-BF) of flaxseed against CCl4-induced liver damage in rats. Journal of pharmacy &bioallied sciences, 4(3), 231.
        • Bhalerao, S., Hegde, M., Ranad, A., Nikam, S., Kshirsagar, K., &Kadam, S. (2010). Studies in the production of Omega 3 enriched chicken meat: II. Indian Journal of Poultry Science, 45(3), 273-279.
        • Bhalerao, S., Hegde, M., Ranade, A., Desai, D., &Kadam, S. (2011). Studies in the production of Omega 3 enriched chicken meat: 1. Indian Journal of Poultry Science, 46(1), 40-45.
        • Bhalerao, S., Hegde, M., Atkare, S., Gondchar, D., Jadhav, R., Kadam, S. (2011). Rural employment through omega-3 chicken production by resourcing linseed as a source of omega-3 fatty acids, J Bombay Vet Coll. 19, 26-29.
        • Bhalerao, S., Hegde, M., Katyare, S., &Kadam, S. (2014). Promotion of omega-3 chicken meat production: an Indian perspective. World's Poultry Science Journal, 70(2), 365-374.
        • Bhalerao, S., Hegde, M., Kadam, S. (2011). Omega-3, Omega-6 fatty acids in human health and disease, Bharati Vidyapeeth (Deemed to be University) Journal 11, 3-9.
        • Mahabaleshwar V. Hegde, Anand A. Zanwar, Shahida A. Khan, Ulhas V. Wagh.Omega-3 fatty acid enriched eggs are heart friendly Atherosclerosis Supplements12(1)1482011
        • Goswami, S., Kandhare, A., Zanwar, A. A., Hegde, M. V., Bodhankar, S. L., Shinde, S., ... &Kharat, R. (2016). Oral l-glutamine administration attenuated cutaneous wound healing in Wistar rats. International wound journal, 13(1), 116-124.
        • Badhe, Y., Kukade, D., Gosavi, T., Karandikar, M., Hegde, M. (2013). Significance of fatty acid analysis in lipid profile. Bharati Vidyapeeth (Deemed to be University) research journal, Volume number 3, 5-15.
        • Mali, A. V., Bhise, S. S., Hegde, M. V., &Katyare, S. S. (2016). Altered erythrocyte glycolytic enzyme activities in type-II diabetes. Indian Journal of Clinical Biochemistry, 31(3), 321-325
        • Mali, A. V., Bhise, S. S., Katyare, S. S., &Hegde, M. V. (2018). Altered kinetics properties of erythrocyte lactate dehydrogenase in type II diabetic patients and its implications for lactic acidosis. Indian Journal of Clinical Biochemistry, 33(1), 38-45.
        • Bhise, S. S., Rao, J. R., Hegde, M. V., &Katyare, S. S. (2020). Compositional alterations in erythrocyte membranes in Type II diabetes. Indian Journal of Experimental Biology (IJEB), 58(10), 671-679.
        • Bhise, S., Rao, J., Hegde, M., &Katyare, S. (2020). Type 2 diabetes differentially affects the substrate saturation kinetic attributes of erythrocyte hexokinase and phosphofructokinase. FEBS letters, 594(2), 240-250.
        • Anand A. Zanwar, Asavari A. Joshi, Prajakta S. Gaikwad, Mahabaleshwar V. Hegde (2024) Type 3 Diabetes Mellitus, Insulin Resistance, Alzheimer, and Role of AlphaLinolenic Acid in Blood–Brain Barrier Repair, CDRP, Chronicle of Diabetes Research and Practice (In Press)
        • Jagtap, A. A., Badhe, Y. S., Farde, P. D., Hegde, M. V., &Zanwar, A. A. (2021). Long-term Storage Stability Assessment of Omega-3-Fatty Acid Emulsified Formulation Containing micronutrients. Journal of Pharmaceutical Innovation, 1-10.
        • Jagtap, A. A., Badhe, Y. S., Hegde, M. V., &Zanwar, A. A. (2021). Development and characterization of stabilized omega-3 fatty acid and micronutrient emulsion formulation for food fortification. Journal of Food Science and Technology, 58(3), 996-1004.
        • Jagtap AA, Joshi AA, Badhe YS, Farde PD, Hegde MV, Zanwar AA. Bioavailability of Omega-3 Fatty Acid In Normal and High Fat High Carbohydrate Diet Induced Animal Model. Metabolism-Clinical and Experimental. 2021 Mar 1;116.
        • 85.Bhat CH, DFarde PR, Vedpathak SM, Hegde MV, ZanwarAA. Efficacy of omega-3-enriched medicated massage oil in Rheumatoid Arthritis: Efficacy of omega-3-enriched medicated massage oil in Rheumatoid Arthritis. Journal of Oilseeds Research.;37(Specialissue).
        • Joshi, A., Hegde, M., &Zanwar, A. (2022). Flaxseed oil and palm olein blend to improve omega-6: Omega-3 ratio. Journal of Food Science and Technology, 59(2), 498-509.
        • Joshi AA, Hegde MV, Zanwar AA. Modulation of essential fatty acid levels in coconut oil with flaxseed oil. Grasas y Aceites. 2023 Jun 13;74(2):e503.
        • Farde PR, Hegde MV, Zanwar AA. Blending of linseed oil with edible oil to improve nutritional quality of edible oil blends. Indian Society of Oilseeds Research.;2021:256.
        • Mahabaleshwar. Hegde, UlhasWagh and Shahida Khan, Omega-3 Fatty acid compositions with honey, World Patent, PCT/IN05/00163 dated 24.05.2005.
        • MahabaleshwarHegde, SurekhaBhalerao, ShivajiraoKadam, Indian patent application No 1971/MUM/2012-Composition for chicken feed for production of Omega-3 Chicken and method thereof. Date of filling: 9-Jul-12, Publication date (U/S 11A)-07-02-2014.
        • Mahabaleshwar V Hegde, Surekha S. Bhalerao, “Omega-3 supplement feed composition for omega -3 eggs production” Indian Patent Application No. 2193/MUM/2014 dated 7-Jul-14.
        • Mahabaleshwar. Hegde, Ulhas Wagh. Nutritional and rejuvenative food supplement capable of fortifying any food products. Application Number 1717/MUM/2012. Publication date (U/S 11A)-14/02/2014
        • Mahabaleshwar Hegde, Anand A. Zanwar, Subhash L. Bodhankar, TejasGosavi, Yogesh S. Badhe. Fortified omega-3 ghee and process for preparation thereof. Indian Full Patent Application-3719/MUM/2013. Publication date (U/S 11A)- 27/12/2013.
        • Shanta Modak, Chathuranga De Silva, Arnabkumar Ghosh, Anand Zanwar, Mahabaleshwar Hegde. Polymer films with antimicrobial agents. International Patent Application No. PCT/US18/44247 WO2019/023685Al. 27/07/2018
        • Shanta Modak,ArnabKumar Ghosh, Chathuranga C. De Silva, Mahabaleshwar Hegde, Anand Zanwar, Santoshkumar Dongre, Shivajirao S. Kadam. Coatings and methods for infection-resistant medical devices. US Provisional Patent Application no. 62333905. Priority date-10-05-2016.
        • "Biochemistry for undergraduate "M.V.Hegde, A.M.Diwan and M.V. Athavale. NarendraPrakashan (1978).
        • A course in Industrial Chemistry" part I: A chapter on Sugar Industries: N.R.Ayyengar, M.V.Hegde, A.J.Mukhedkar, N.S.Narasimhan, P.G.Pol and A.C.Ranade. Orient Longman (1977).
        • "A course in Industrial Chemistry" part II : A chapter on Fermentation Industries : M.V.Hegde, S.B.Kulkarni, A.J.Mukhedkar, P.G.Pol and D.L. Roy. Orient Longman (1978).
        • Mahabaleshwar V. Hegde, Anand A. Zanwar, Sharad P. Adekar. Omega-3 Fatty Acids - Keys to Nutritional Health 2016. Humana Press Springer Science. Springer International Publishing Switzerland. DOI: 10.1007/978-3-319-40458-5. ISBN: 978-3-319-40456-1 (Print) 978-3-319-40458-5 (Online).
        • A course in Industrial Chemistry" part I: A chapter on Sugar Industries: N.R.Ayyengar, M.V.Hegde, A.J.Mukhedkar, N.S.Narasimhan, P.G.Pol and A.C.Ranade. Orient Longman (1977).
        • "A course in Industrial Chemistry" part II : A chapter on Fermentation Industries : M.V.Hegde, S.B.Kulkarni, A.J.Mukhedkar, P.G.Pol and D.L. Roy. Orient Longman (1978).
        • “Cultural and Socioeconomic Differences in Dietary Intake of Essential Fatty Acids and Antioxidants: Effects on the Course and Outcome of Schizophrenia.” Sahebrao P. Mahadik, MeenaMulchandani, Mahabaleshwar. Hegde and Prabhakar K. Ranjekar. A chapter in “Phospholipid spectrum Disorders in Psychiatry” (1998).
        • M V Hegde. PB Ghorpade, AA Zanwar and DM Hegde, New Avenues of for value addition in oil seeds in vegetable oils scenario: Approaches to meet the growing demands Published by Indian Society of Oil Seed Research Hyderabad 2009, Pages 292-313.
        • Anand A. Zanwar, Sachin L. Badole, Pankaj S. Shende, Mahabaleshwar V. Hegde and Subhash L. Bodhankar, Chapter 76 - Cardiovascular Effects of Hesperidin: A Flavanone Glycoside, In Polyphenols in Human Health and Disease, edited by Ronald Ross Watson, Victor R. Preedy and ShermaZibadi, Academic Press- Elsevier Inc., San Diego, 2014, Pages 989-992, ISBN 9780123984562
        • Anand A. Zanwar, Sachin L. Badole, Pankaj S. Shende, Mahabaleshwar V. Hegde and Subhash L. Bodhankar, Chapter 80 - Role of Gallic Acid in Cardiovascular Disorders, In Polyphenols in Human Health and Disease, edited by Ronald Ross Watson, Victor R. Preedy and ShermaZibadi, Academic Press- Elsevier Inc., San Diego, 2014, Pages 1045-1047, ISBN 9780123984562.
        • Anand A. Zanwar, Sachin L. Badole, Pankaj S. Shende, Mahabaleshwar V. Hegde and Subhash L. Bodhankar, Chapter 21 - Antioxidant Role of Catechin in Health and Disease, In Polyphenols in Human Health and Disease, edited by Ronald Ross Watson, Victor R. Preedy and ShermaZibadi, Academic Press- Elsevier Inc., San Diego, 2014, Pages 267-271, ISBN 9780123984562.
        • Anand A. Zanwar, Mahabaleshwar V. Hegde and Subhash L. Bodhankar, Chapter 71 - Flax Lignan in the Prevention of Atherosclerotic Cardiovascular Diseases, In Polyphenols in Human Health and Disease, edited by Ronald Ross Watson, Victor R. Preedy and ShermaZibadi, Academic Press- Elsevier Inc., San Diego, 2014, Pages 915-921, ISBN 9780123984562.
        • Mahabaleshwar V. Hegde Anand A. Zanwar, Sharad P. Adekar. Nutrition, Life, Disease, and Death. In Omega-3 Fatty Acids - Keys to Nutritional Health. Humana Press Springer Science. 2016, Chapter 01; 1-10
        • Mahabaleshwar V. Hegde Anand A. Zanwar, Prakash B. Ghorpade. Flax Bio-village Concept. In Omega-3 Fatty Acids - Keys to Nutritional Health. Humana Press Springer Science. 2016, Chapter 02; 11-20
        • Anand Arvind Zanwar, Yogesh S. Badhe, Subhash L. Bodhankar, Prakash B. Ghorpade, Mahabaleshwar V. Hegde.Flax Bio-village Concept. In Omega-3 Fatty Acids - Keys to Nutritional Health. Humana Press Springer Science. 2016, Chapter 04; 45-50
        • Manohar L. Panse, Shripad P.Atakare, Mahabaleshwar V. Hegde, Shivajirao S. Kadam. Omega-3 Egg. In Omega-3 Fatty Acids - Keys to Nutritional Health. Springer Science + Business Media publisher, Switzerland.2016.Chapter 5,P.51-66
        • Asavari A. Joshi, Mahabaleshwar V. Hegde and Sharad P. Adekar. Omega-3 Fatty Acids in Cancer: Insight into the Mechanism of Actions in Preclinical Cancer Models. In: Omega-3 Fatty Acids – Keys to Nutritional Health. Humana Press Springer Science. 2016, Chapter 12;:157-172
        • Anand A. Zanwar, Asavari A. Joshi, Mahabaleshwar V. Hegde. Effects of dietary Omega-3 fatty acid consumption. In Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases. Academic Press- Elsevier Inc. 2017, Chapter No. 25; 385-395.

 

Apply For

ADMISSIONS 2023
mobile-chat

Chat Now

 mobile-phone

Admission Helpline +91-20-24407100

mobile-inquiry

Quick Enquiry
National Immunogenicity & Biologics Evaluation Center ICMR Centre for Advanced Research Indian Council of Agricultural Research-LVAC
communicable-diseases Communicable Diseases obesity-and-diabetes Obesity & Diabetes cancer Cancer Research Lab herbal-medicine Herbal Medicine nutrition-health-disease Centre for Innovation in Nutrition Health Disease mother-and-child-health Mother & Child Health